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KMID : 0385020010170040245
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Korean Journal of Laboratory Animal Science
2001 Volume.17 No. 4 p.245 ~ p.250
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Expression of Heat Shock Protein 25 in Mouse Cerebellum and Pons
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Lee, Nam Seob
Jeong, Young Gil/Chung, Seung Hyuk
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Abstract
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Exposure to heat shock and other stressful conditions activates in cells of all organisms a specific genetic program. This enhances the synthesis of proteins with a protective role against cellular damage, celled heat shock proteins (lisp). Furthermore, in the mammalian nervous system, a considerable amount of Hsp is also synthesized under normal conditions suggesting that they play an important role in the metabolism of unstressed cells. In this present study, despite the reported absence of the 25-kDa heat shack protein Hsp25 in the rodent cerebellum and pons, we have observed that Hsp25 is constitutively expressed in a subset of Purkinje cells in the mouse cerebellum, spinal trigemimal tract (spV) and facial nuclues (fac) of pons. No other cerebellar neurons are Hsp25 immunoreactive, but there is a weak staining associated with blood vessels. In the cerebellar vermis, Hsp25-immunoreactive Purkinje cells are confined to two regions: confined to the caudal central zone (VI/VII), the nodular zone (IX and X), and the paraflocculi/flocculi. One group is in lobules VI/VII, the other group is in lobules IX/X and only a subset of the Purkinje cells is immunoreactive. These cells are grouped in parasaglttal bands arranged symmetrically about the midline. A third Hsp25-immunopositive Purkinje cells is seen in the paraflocculus and flocculus. Moreover, Hsp25-immunoreactive cells were observed in the in various sensory and motor neurons of the pons. Especially, Hsp25-immunoreactive neurons were seen in fac and spV.
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